N-nitroso-N-substituted hydroxylamines as nitric oxide donors Patent uri icon


  • Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.

author list (cited authors)

  • Garfield, R., Balaban, A., Seitz, W., Klein, D., & Lesko, M.

complete list of authors

  • Garfield, Robert||Balaban, Alexandru||Seitz, William||Klein, Douglas||Lesko, Melanie

publication date

  • December 1997