Interactions of metal-metal-bonded antitumor active complexes with DNA fragments and DNA. Academic Article

abstract

• This Account summarizes the DNA binding properties of anticancer active dinuclear Rh, Re, and Ru compounds. The combined results of NMR spectroscopy, X-ray crystallography, and various biochemical tools provide incontrovertible evidence that dinuclear complexes are favorably poised to bind to purine nucleobases, DNA fragments, and double-stranded DNA. Moreover, direct DNA photocleavage in vitro is effected by dirhodium compounds in the presence of electron acceptors in solution or directly attached to the dirhodium core. This research has provided valuable insight in the interactions of dinuclear compounds with DNA, knowledge that is an excellent backdrop for rational design of promising dinuclear drugs.

authors

• Dunbar, Kim

published proceedings

• Acc Chem Res

altmetric score

• 6

author list (cited authors)

• Chifotides, H. T., & Dunbar, K. R.

citation count

• 402

complete list of authors

• Chifotides, Helen T||Dunbar, Kim R

publication date

• February 2005

publisher

• American Chemical Society (ACS)  Publisher

published in

• Accounts of Chemical Research  Journal

keywords

• Antineoplastic Agents
• Binding Sites
• DNA
• DNA Adducts
• Metals, Heavy
• Models, Molecular
• Molecular Conformation
• Organometallic Compounds

PubMed Central ID

• 15709734

Digital Object Identifier (DOI)

• 10.1021/ar0302078

start page

• 146

end page

• 156

volume

• 38

issue

• 2

URL

• http://dx.doi.org/10.1021/ar0302078