Ruthenium(II) complexes of 1,12-diazaperylene and their interactions with DNA. Academic Article uri icon

abstract

  • Four complexes of the ligand 1,12-diazaperylene (DAP) have been prepared, [Ru(bpy)n(DAP)(3-n)]2+ where n = 0-2 and [Ru(DAP)3]2+. The [Ru(DAP)3]2+ complex was characterized by X-ray analysis and was found to exhibit the expected propeller-like structure with significant intermolecular pi-stacking interactions. The three Ru(II) complexes showed self-consistent optoelectronic properties with similar ligand-centered pi-pi* absorptions in the range of 333-468 nm and MLCT bands associated with the DAP which increased in intensity and decreased in energy as the number of DAP ligands varied from 1 to 3. Hypochromicity and viscosity changes were observed that were consistent with DAP intercalation into DNA, and binding constants were measured in the range of 1.4-1.6 x 10(6) M(-1) for the mixed ligand complexes. Furthermore, the complex [Ru(bpy)2(DAP)]2+ was found to photocleave plasmid DNA upon irradiation with visible light.

published proceedings

  • Inorg Chem

author list (cited authors)

  • Chouai, A., Wicke, S. E., Turro, C., Bacsa, J., Dunbar, K. R., Wang, D., & Thummel, R. P.

citation count

  • 114

complete list of authors

  • Chouai, Abdellatif||Wicke, Sara E||Turro, Claudia||Bacsa, John||Dunbar, Kim R||Wang, Dong||Thummel, Randolph P

publication date

  • August 2005