Transmitters Location Optimization for Drug Delivery Systems
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abstract
2018 Association for Computing Machinery. Drug Delivery Systems (DDSs) are of vital importance to treat dangerous diseases, such as cancer. The goal of DDSs is to provide the required medication to the diseased area without affecting other healthy parts of the body. Most advanced DDSs use nanoparticles since they are able to cross biological barriers, but it has been shown that about 1% of injected nanoparticles are delivered to the diseased area. Molecular Communication (MC) paradigm is used to study DDSs, in particular to model the propagation of nanoparticles by advection and diffusion throughout the cardiovascular system in order to maximize the amount of nanoparticles reaching the diseased area. While existing work proposes different methods to tackle this problem, none of them aim to identify the optimal transmitters location to inject nanoparticles such that they reach the intended target while avoiding other areas in the body. In this paper, we propose an optimization problem to determine the optimal placement of transmitters to achieve a desired signal strength at a target organ, while ensuring that the interference at the organs we intend to avoid is below a threshold.We consider different scenarios to study how the transmitters location are affected by the desired signal strength for the target, and the threshold interference at the regions to avoid.We find that the choice of the target and avoidance regions, and the model of the circulatory system have a significant impact on the transmitters location.
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Proceedings of the 5th ACM International Conference on Nanoscale Computing and Communication
