[Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent.

abstract

• The cation cis-[Ru(bpy)(2)(5CNU)(2)](2+) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)(2)(H(2)O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.

authors

• Dunbar, Kim

published proceedings

• Inorg Chem

altmetric score

• 3

author list (cited authors)

• Garner, R. N., Gallucci, J. C., Dunbar, K. R., & Turro, C.

citation count

• 131

complete list of authors

• Garner, Robert N||Gallucci, Judith C||Dunbar, Kim R||Turro, Claudia

publication date

• October 2011

publisher

• American Chemical Society (ACS)  Publisher

published in

• Inorganic Chemistry  Journal

keywords

• 2,2'-Dipyridyl
• Coordination Complexes
• DNA
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Molecular Dynamics Simulation
• Organometallic Compounds
• Photolysis
• Ruthenium
• Spectrophotometry, Ultraviolet
• Uracil

PubMed Central ID

• 21879748

Digital Object Identifier (DOI)

• 10.1021/ic201615u

start page

• 9213

end page

• 9215

volume

• 50

issue

• 19

URL

• http://dx.doi.org/10.1021/ic201615u