[Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent. Academic Article uri icon

abstract

  • The cation cis-[Ru(bpy)(2)(5CNU)(2)](2+) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)(2)(H(2)O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.

published proceedings

  • Inorg Chem

altmetric score

  • 3

author list (cited authors)

  • Garner, R. N., Gallucci, J. C., Dunbar, K. R., & Turro, C.

citation count

  • 125

complete list of authors

  • Garner, Robert N||Gallucci, Judith C||Dunbar, Kim R||Turro, Claudia

publication date

  • August 2011