Intermolecular Ritter-type C-H amination of unactivated sp3 carbons. Academic Article uri icon


  • Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C-H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.

published proceedings

  • J Am Chem Soc

altmetric score

  • 20.274

author list (cited authors)

  • Michaudel, Q., Thevenet, D., & Baran, P. S.

citation count

  • 231

complete list of authors

  • Michaudel, Quentin||Thevenet, Damien||Baran, Phil S

publication date

  • February 2012