Hydromethylation of Unactivated Olefins. Academic Article uri icon


  • A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly "edit" complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.

published proceedings

  • J Am Chem Soc

altmetric score

  • 15.35

author list (cited authors)

  • Dao, H. T., Li, C., Michaudel, Q., Maxwell, B. D., & Baran, P. S

citation count

  • 106

complete list of authors

  • Dao, Hai T||Li, Chao||Michaudel, Quentin||Maxwell, Brad D||Baran, Phil S

publication date

  • July 2015