The Effects of Sertraline on Fathead Minnow (Pimephales promelas) Growth and Steroidogenesis.
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abstract
The purpose of this study was to evaluate the steroidogenic effects of sertraline, a popular selective serotonin reuptake inhibitor, on larval fathead minnow (FHM; Pimephales promelas) and adult FHM. Larvae were exposed to 0.1, 1, and 10g/L sertraline for 28 days and analyzed for differential mRNA expression of 11-hydroxysteroid dehydrogenase (11-HSD), 20-hydroxysteroid dehydrogenase (20-HSD), aromatase (CYP19a), nuclear thyroid receptor alpha (TR), and normalized to RP-L8. Adult FHM were exposed to 3 or 10g/L sertraline for 7 days and analyzed for differential expression of the same genes with the addition of thyroid receptor beta (TR). Larval FHM exposed to 0.1g/L had a significant upregulation of both 20-HSD and TR while adult FHM exposed to 10g/L had a significant upregulation of 11-HSD expression in brain tissue. The significance of these findings with respect to survival, growth and reproduction are currently unknown, but represent areas for future research.