Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy. Academic Article

abstract

• Pregnancy-associated glycoproteins (PAGs) are abundantly expressed products of the placenta of species within the Cetartiodactyla order (even-toed ungulates). They are restricted to this order and they are particularly numerous in the Bovidae. The PAGs exhibit a range of temporal and spatial expression patterns by the placental trophoblasts and probably represent a group of related proteins that perform a range of distinct functions in the epitheliochorial and synepitheliochorial placental forms. This review presents an overview of the origins of the PAGs, a summary of PAG expression patterns, and their use as markers of pregnancy status. Speculations about their putative role(s) in pregnancy are also presented.

authors

• Pohler, Ky

published proceedings

• Reproduction

altmetric score

• 0.5

author list (cited authors)

• Wallace, R. M., Pohler, K. G., Smith, M. F., & Green, J. A.

citation count

• 79

complete list of authors

• Wallace, Rhianna M||Pohler, Ky G||Smith, Michael F||Green, Jonathan A

publication date

• March 2015

publisher

• Bioscientifica  Publisher

published in

• REPRODUCTION  Journal

keywords

• Animals
• Artiodactyla
• Female
• Gene Expression
• Glycoproteins
• Placenta
• Pregnancy
• Pregnancy Proteins

PubMed Central ID

• 25661256

Digital Object Identifier (DOI)

• 10.1530/REP-14-0485
• 10.1530/rep-14-0485

start page

• R115
• r115

end page

• R126
• r126

volume

• 149

issue

• 3