Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy. Academic Article uri icon


  • Pregnancy-associated glycoproteins (PAGs) are abundantly expressed products of the placenta of species within the Cetartiodactyla order (even-toed ungulates). They are restricted to this order and they are particularly numerous in the Bovidae. The PAGs exhibit a range of temporal and spatial expression patterns by the placental trophoblasts and probably represent a group of related proteins that perform a range of distinct functions in the epitheliochorial and synepitheliochorial placental forms. This review presents an overview of the origins of the PAGs, a summary of PAG expression patterns, and their use as markers of pregnancy status. Speculations about their putative role(s) in pregnancy are also presented.

published proceedings

  • Reproduction

altmetric score

  • 0.5

author list (cited authors)

  • Wallace, R. M., Pohler, K. G., Smith, M. F., & Green, J. A.

citation count

  • 95

complete list of authors

  • Wallace, Rhianna M||Pohler, Ky G||Smith, Michael F||Green, Jonathan A

publication date

  • March 2015