Glucocorticoid regulation of hippocampal oxytocin receptor binding. Academic Article

abstract

• The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [125I]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.

authors

• Liberzon, Israel

published proceedings

• Brain Res

author list (cited authors)

• Liberzon, I., Chalmers, D. T., Mansour, A., Lopez, J. F., Watson, S. J., & Young, E. A.

citation count

• 31

complete list of authors

• Liberzon, I||Chalmers, DT||Mansour, A||Lopez, JF||Watson, SJ||Young, EA

publication date

• July 1994

publisher

• Elsevier  Publisher

published in

• BRAIN RESEARCH  Journal

keywords

• Adrenalectomy
• Animals
• Corticosterone
• Glucocorticoids
• Hippocampus
• Male
• Rats
• Rats, Sprague-Dawley
• Receptors, Oxytocin
• Vasotocin

PubMed Central ID

• 7953698

Digital Object Identifier (DOI)

• 10.1016/0006-8993(94)91798-1

start page

• 317

end page

• 322

volume

• 650

issue

• 2

URL

• http://dx.doi.org/10.1016/0006-8993(94)91798-1