Brain-imaging studies of posttraumatic stress disorder. Academic Article

abstract

• Brain-imaging studies of posttraumatic stress disorder (PTSD) have rapidly increased in recent years. Structural studies have identified potential smaller volumes of the hippocampus of traumatized and/or PTSD subjects. Functional activation studies have implicated hyperactive or altered functioning of brain regions, such as the amygdala and the insula, and a failure to engage emotional regulatory structures, such as the medial prefrontal and anterior cingulate cortex. Recent neurochemical investigations have suggested that neuromodulatory systems (eg, gamma-aminobutyric acid, micro-opioid) may underlie these aberrant brain activation patterns. This article reviews the literature on structural, functional, and neurochemical brain-imaging studies of PTSD.

authors

• Liberzon, Israel

published proceedings

• CNS Spectr

author list (cited authors)

• Liberzon, I., & Phan, K. L.

citation count

• 79

complete list of authors

• Liberzon, Israel||Phan, K Luan

publication date

• September 2003

publisher

• Cambridge University Press (CUP)  Publisher

published in

• CNS Spectrums: the international journal of neuropsychiatric medicine  Journal

keywords

• Brain
• Brain Mapping
• Diagnostic Imaging
• Emotions
• Humans
• Neurotransmitter Agents
• Stress Disorders, Post-Traumatic

PubMed Central ID

• 15079138

Digital Object Identifier (DOI)

• 10.1017/s109285290000883x

start page

• 641

end page

• 650

volume

• 8

issue

• 9

URL

• http://dx.doi.org/10.1017/s109285290000883x