Neuroimaging studies of emotional responses in PTSD. Academic Article

abstract

• Neuroimaging research offers a powerful and noninvasive means to understand healthy as well as dysregulated emotional processing in healthy subjects and PTSD patients. Functional neuroimaging findings suggest specific roles for subregions of the medial prefrontal (mPFC), orbito frontal (OFC), anterior cingulate (ACC), and insular cortices as well as the sublenticular extended amygdala (SLEA) and hippocampus in various components of emotional processing. Some of the same regions appear to be associated with emotional response to trauma, and with symptom formation in PTSD. Neuroimaging findings of emotional processing in healthy subjects and PTSD patients are discussed, addressing the specific roles of cortical regions like mPFC, ACC, and insula, and their potential contribution to PTSD pathophysiology. Processes of cognitive-emotional interactions and social emotions are discussed in an attempt to synthesize the prefrontal findings in healthy subjects and PTSD patients. Further links between functional neuroanatomy of emotional responses and neuroendocrine stress regulation are proposed.

authors

• Liberzon, Israel

published proceedings

• Ann N Y Acad Sci

altmetric score

• 4

author list (cited authors)

• Liberzon, I., & Martis, B.

citation count

• 170

complete list of authors

• Liberzon, Israel||Martis, Brian

publication date

• July 2006

publisher

• Wiley  Publisher

published in

• Annals of the New York Academy of Sciences  Journal

keywords

• Brain
• Cross-Sectional Studies
• Diagnostic Imaging
• Emotions
• Humans
• Neurosecretory Systems
• Stress Disorders, Post-Traumatic

PubMed Central ID

• 16891565

Digital Object Identifier (DOI)

• 10.1196/annals.1364.009

start page

• 87

end page

• 109

volume

• 1071

issue

• 1

URL

• http://dx.doi.org/10.1196/annals.1364.009