Optogenetic approaches to control calcium entry in non-excitable cells
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© 2017 by Taylor & Francis Group, LLC. The calcium ion serves as a versatile and universal second messenger to control a myriad of biological processes, including muscle contraction, neurotransmission, hormone secretion, immune cell activation, cell motility, and apoptosis [1-3]. The calcium release-activated calcium (CRAC) channel mediated by ORAI and stromal interaction molecule (STIM) constitutes one of the primary Ca2++ entry routes in non-excitable cells [4-6] (see Chapter 2). The CRAC channel is regarded as a prototypical example of store-operated Ca2++ entry (SOCE), in which the depletion of Ca2++ store in the endoplasmic reticulum (ER) induces calcium inux from the extracellular space. Over the past decade, tremendous progress has been made with respect to.
author list (cited authors)
He, L., Zhang, Q., Zhou, Y., & Huang, Y.
Calcium Entry Channels in Non-Excitable Cells