Optogenetic approaches to control calcium entry in non-excitable cells Chapter uri icon

abstract

  • © 2017 by Taylor & Francis Group, LLC. The calcium ion serves as a versatile and universal second messenger to control a myriad of biological processes, including muscle contraction, neurotransmission, hormone secretion, immune cell activation, cell motility, and apoptosis [1-3]. The calcium release-activated calcium (CRAC) channel mediated by ORAI and stromal interaction molecule (STIM) constitutes one of the primary Ca2++ entry routes in non-excitable cells [4-6] (see Chapter 2). The CRAC channel is regarded as a prototypical example of store-operated Ca2++ entry (SOCE), in which the depletion of Ca2++ store in the endoplasmic reticulum (ER) induces calcium inux from the extracellular space. Over the past decade, tremendous progress has been made with respect to.

altmetric score

  • 1.35

author list (cited authors)

  • He, L., Zhang, Q., Zhou, Y., & Huang, Y.

citation count

  • 14

Book Title

  • Calcium Entry Channels in Non-Excitable Cells

publication date

  • January 2017