Protection of organophosphate-inactivated esterases with phosphotriesterase. Academic Article

abstract

• The protective effect of phosphotriesterase (PTE) on cholinesterase (ChE) and carboxylesterase (CaE) activities was studied in mice. The PTE pretreatment (120 U/g body wt, 9.6 micrograms/g body wt) given i.v. 10 min before diisopropyl fluorophosphate, sarin, or soman variably prevented ChE inhibition in erythrocytes and plasma and CaE in plasma. PTE also protected the brain and lung ChEs against inactivation by organophosphates (OPs). The recovery of the enzymes was dependent on the OP used. Postexposure therapy with PTE, given 1.5 hr after paraoxon, also prevented ChE inhibition in erythrocytes, brain, and lung 24 hr after exposure. The distribution studies with [125I]PTE showed that PTE does not markedly gain access into the central nervous system.

authors

• Raushel, Frank

published proceedings

• Fundam Appl Toxicol

author list (cited authors)

• Tuovinen, K., Kaliste-Korhonen, E., Raushel, F. M., & Hnninen, O.

citation count

• 18

complete list of authors

• Tuovinen, K||Kaliste-Korhonen, E||Raushel, FM||Hänninen, O

publication date

• January 1996

publisher

• Elsevier  Publisher

published in

• Fundamental and applied toxicology : official journal of the Society of Toxicology  Journal

keywords

• Animals
• Aryldialkylphosphatase
• Biological Availability
• Brain
• Cholinesterase Inhibitors
• Drug Antagonism
• Esterases
• Isoflurophate
• Lung
• Male
• Mice
• Sarin
• Soman
• Time Factors

Digital Object Identifier (DOI)

• 10.1006/faat.1996.0093

start page

• 210

end page

• 217

volume

• 31

issue

• 2

URL

• http://dx.doi.org/10.1006/faat.1996.0093