Carbamoyl phosphate synthetase: a tunnel runs through it. Academic Article uri icon


  • The direct transfer of metabolites from one protein to another in a biochemical pathway or between one active site and another within a single enzyme has been described as substrate channeling. The first structural visualization of such a phenomenon was provided by the X-ray crystallographic analysis of tryptophan synthase, in which a tunnel of approximately 25 A in length was observed. The recently determined three-dimensional structure of carbamoyl phosphate synthetase sets a new long distance record in that the three active sites are separated by nearly 100 A.

published proceedings

  • Curr Opin Struct Biol

altmetric score

  • 3

author list (cited authors)

  • Holden, H. M., Thoden, J. B., & Raushel, F. M.

citation count

  • 37

complete list of authors

  • Holden, HM||Thoden, JB||Raushel, FM

publication date

  • December 1998