Phosphotriesterase: an enzyme in search of its natural substrate. Academic Article uri icon


  • The bacterial PTE is able to catalyze the hydrolysis of a wide range of organophosphate nerve agents. The active site has been shown to consist of a unique binuclear metal center that has evolved to deliver hydroxide to the site of bond cleavage. The reaction rate for the hydrolysis of activated substrates such as paraoxon is limited by product release or an associated protein conformational change.

published proceedings

  • Adv Enzymol Relat Areas Mol Biol

author list (cited authors)

  • Raushel, F. M., & Holden, H. M.

citation count

  • 86

complete list of authors

  • Raushel, FM||Holden, HM

publication date

  • January 2000