Evolution of function in (beta/alpha)8-barrel enzymes.

abstract

• The (beta/alpha)(8)-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (beta/alpha)(8)-barrel containing enzymes.

authors

• Raushel, Frank

published proceedings

• Curr Opin Chem Biol

altmetric score

• 3

author list (cited authors)

• Gerlt, J. A., & Raushel, F. M.

citation count

• 129

complete list of authors

• Gerlt, John A||Raushel, Frank M

publication date

• January 2003

publisher

• Elsevier  Publisher

published in

• Current Opinion in Chemical Biology  Journal

keywords

• Animals
• Biological Evolution
• Directed Molecular Evolution
• ENZYMES
• Humans
• Models, Molecular
• Protein Conformation

Digital Object Identifier (DOI)

• 10.1016/s1367-5931(03)00019-x

start page

• 252

end page

• 264

volume

• 7

issue

• 2

URL

• http://dx.doi.org/10.1016/s1367-5931(03)00019-x