Controlled release coprecipitates: formulation considerations Academic Article uri icon


  • Extended release dosage forms can be prepared by a number of methods and coprecipitation of drugs with polymers is one of them. Coprecipitation in turn can be achieved by several methods and dissolution of drugs and polymer in a solvent followed by the addition of a non-solvent with agitation is one of them. The objective of this study was to investigate the possibility of preparing compressed tablets of certain novel coprecipitates reported recently. Besides determining the drug-additive interactions with differential scanning calorimetry, the effect of formulation variables on the cumulative percent of drug released, hardness and thickness of the tablets was investigated. The results indicated that diluents, lubricant to glidant ratio and compression pressure considerably affect the responses. A 3 3 Latin square design was employed to optimize the levels of variables to achieve the desired responses. The tablets were found to be fairly stable at room temperature for nine months. A comparative evaluation of the tablets prepared from coprecipitates, solid dispersions, and physical mixtures indicated the most efficient release from coprecipitates. 1995.

published proceedings

  • Journal of Controlled Release

altmetric score

  • 3

author list (cited authors)

  • Khan, M. A., Karnachi, A. A., Singh, S. K., Sastry, S. V., Kislalioglu, S. M., & Bolton, S.

citation count

  • 27

complete list of authors

  • Khan, Mansoor A||Karnachi, Anees A||Singh, Shailesh K||Sastry, Srikonda V||Kislalioglu, Serpil M||Bolton, Sanford

publication date

  • November 1995