Effect of Additives on the Diffusion of Ketoprofen Through Human Skin Academic Article

abstract

• The influence of Carbopol polymer, types C-934P and C-940, and the penetration enhancer oleic acid on transdermal permeation of ketoprofen through a full-thickness human skin was investigated. Ketoprofen patches were fabricated; and permeation parameters such as the flux, permeability coefficient, enhancement ratio, lag time, and partition coefficients were determined. The results indicated a maximum flux of 7.778 g/cm2/hr from the patches made with C-934P when the oleic acid concentration was 35%. The enhancement ratio was 22.8. The maximum flux value for patches made from C-940 was obtained with 10% oleic acid. The corresponding enhancement ratio was 34.25. The results indicated that the concentration of oleic acid needed for maximum flux depends upon the type of Carbopol polymer selected for the study. Further, ketoprofen transdermal drug delivery systems can be fabricated to obtain a zero-order release through human skin.

authors

• Khan, Mansoor
• Reddy, Indra

published proceedings

• Drug Development and Industrial Pharmacy

author list (cited authors)

• Singh, S. K., Roane, D. S., Reddy, L. K., Durrani, M. J., & Khan, M. A.

citation count

• 9

complete list of authors

• Singh, Shailesh K||Roane, David S||Reddy, Lndra K||Durrani, Manzer J||Khan, Mansoor A

publication date

• January 1996

publisher

• Taylor & Francis  Publisher

published in

• n0363-9045ISSN  Journal

Digital Object Identifier (DOI)

• 10.3109/03639049609069357

start page

• 471

end page

• 474

volume

• 22

issue

• 5

URL

• http://dx.doi.org/10.3109/03639049609069357