Controlled drug delivery Development of solid oral dosage forms with acrylate polymers

The objective of the present article is to provide an overview of the use of aery late polymers in the development of solid oral dosage forms. While several acrylate polymers have been reported for use in oral controlled drug delivery, the present article focuses on the development, optimization, characterization, and in vitro/in vivo evaluation of drug coprecipitates with Eudragit polymers. A systematic approach entailing the selection of proper Eudragit polymer for preparing controlled-release tablet dosage forms is presented. The steps include screening several polymers and formulation variables to obtain the coprecipitates as granules or micromatrices. The coprecipitation study is followed by the evaluation of formulation and process variables that determine the quality of the dosage form. Further, an in vivo study on bioavailability/bioequivalence of a controlled- release dosageform obtained with Eudragit S100 is reported. The studies presented indicate that anionic and zwitterionic acrylate polymers are very useful for obtaining controlled-release solid dosage forms. Finally, a systematic approach for the evaluation of factors that affect the release behavior of atenolol from bilayered, osmotically controlled release tablets prepared with crosslinked acrylate polymers are discussed.

Controlled drug delivery Development of solid oral dosage forms with acrylate polymers Academic Article