Optimization of process variables for the preparation of ibuprofen coprecipitates with eudragit S100

abstract

• The objective of this study was to optimize the technique used to prepare extended release coprecipitates of ibuprofen with Eudragit S100. The technique involved dissolution of ibuprofen and Eudragit S100 in alcohol USP followed by the addition of cold water with agitation for a specified length of time. A four-factor full factorial design with agitation time and speed and volumes of alcohol and water was used for optimization. The dependent variables were percent recovery of ibuprofen, flowability index and geometric mean diameter of the coprecipitated granules. Mathematical relationships and response surface plots were obtained to relate the dependent and independent variables. Optimization was performed by the grid search and computer methods. 1994.

authors

• Khan, Mansoor

published proceedings

• International Journal of Pharmaceutics

author list (cited authors)

• Khan, M. A., Bolton, S., & Kislalioglu, M. S.

citation count

• 27

complete list of authors

• Khan, MA||Bolton, S||Kislalioglu, MS

publication date

• February 1994

publisher

• Elsevier  Publisher

published in

• International Journal of Pharmaceutics  Journal

Digital Object Identifier (DOI)

• 10.1016/0378-5173(94)90054-x

start page

• 185

end page

• 192

volume

• 102

issue

• 1-3

URL

• http://dx.doi.org/10.1016/0378-5173(94)90054-x