Current status of the oral delivery of insulin
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abstract
The authors summarize the current status of the development strategies of insulin drug delivery systems in the pharmaceutical industry, various challenges associated with the oral delivery of insulin, and how these challenges may be overcome by the use of enzyme inhibitors, permeation enhancers, and polymeric systems. The authors also discuss a novel dosage form that incorporates the dual controlled release of insulin and inhibitor and a dosage form that consists of immobilized inhibitor.