surface roughness, and in vitro dissolution of a self-nanoemulsified solid dosage form of ubiquinone Effect of extragranular microcrystalline cellulose: On compaction

The authors evaluate the effect of microcrystalline cellulose (MCC) on the tableting performance, surface roughness, and dissolution properties of a dry adsorbed self-nanoemulsified powdered formulation. Heckel analysis was used to study the tabletability, compressibility, and compactibility of six formulas prepared with various MCC grades. Surface topography revealed a higher degree of waviness at the lower surface of the compacts as the result of granule segregation. The dissolution rate of the nanoemulsion from the tablets increased with increasing MCC particle size. Good flow properties of the formulations resulted from the granular nature of the mixtures. Low hardness and friability indicated oil-induced bridging between the particles.

Effect of extragranular microcrystalline cellulose: On compaction, surface roughness, and in vitro dissolution of a self-nanoemulsified solid dosage form of ubiquinone Academic Article