W. W. "Mo" Cleland: a catalytic life. Academic Article

abstract

• Professor W. Wallace Cleland, the architect of modern steady-state enzyme kinetics, died on March 6, 2013, from injuries sustained in a fall outside of his home. He will be most remembered for giving the enzyme community Ping-Pong kinetics and the invention of dithiothreitol (DTT). He pioneered the utilization of heavy atom isotope effects for the elucidation of the chemical mechanisms of enzyme-catalyzed reactions. His favorite research journal was Biochemistry, in which he published more than 135 papers beginning in 1964 with the disclosure of DTT.

authors

• Raushel, Frank

published proceedings

• Biochemistry

altmetric score

• 0.5

author list (cited authors)

• Dunaway-Mariano, D., Holden, H. M., & Raushel, F. M.

citation count

• 5

complete list of authors

• Dunaway-Mariano, Debra||Holden, Hazel M||Raushel, Frank M

publication date

• December 2013

publisher

• American Chemical Society (ACS)  Publisher

published in

• Biochemistry  Journal

keywords

• Biocatalysis
• Biochemistry
• Deuterium Exchange Measurement
• Dithiothreitol
• ENZYMES
• Enzyme Inhibitors
• History, 20th Century
• History, 21st Century
• Kinetics
• Malate Dehydrogenase (NADP+)
• Models, Biological
• Oxidation-Reduction
• Philately
• Proteins
• Reducing Agents
• Spectrophotometry
• Sulfhydryl Reagents
• United States
• Wisconsin

PubMed Central ID

• 24308306

Digital Object Identifier (DOI)

• 10.1021/bi4015709

start page

• 9092

end page

• 9096

volume

• 52

issue

• 51

URL

• http://dx.doi.org/10.1021/bi4015709