W. W. "Mo" Cleland: a catalytic life. Academic Article uri icon


  • Professor W. Wallace Cleland, the architect of modern steady-state enzyme kinetics, died on March 6, 2013, from injuries sustained in a fall outside of his home. He will be most remembered for giving the enzyme community Ping-Pong kinetics and the invention of dithiothreitol (DTT). He pioneered the utilization of heavy atom isotope effects for the elucidation of the chemical mechanisms of enzyme-catalyzed reactions. His favorite research journal was Biochemistry, in which he published more than 135 papers beginning in 1964 with the disclosure of DTT.

published proceedings

  • Biochemistry

altmetric score

  • 0.5

author list (cited authors)

  • Dunaway-Mariano, D., Holden, H. M., & Raushel, F. M.

citation count

  • 5

complete list of authors

  • Dunaway-Mariano, Debra||Holden, Hazel M||Raushel, Frank M

publication date

  • December 2013