Effect of menthol on permeability of an optically active and racemic propranolol across guinea pig skin.

abstract

• The effect of menthol on the percutaneous penetration of S(-)-propranolol (SPL) and racemic form of propranolol (RSPL) was investigated in vitro using excised abdominal skin of guinea pig. In the presence of menthol, the permeability coefficient of SPL was high compared with that of RSPL. The enhancement factors for SPL and RSPL were 2.12 and 0.85, respectively. The lag times for SPL and RSPL were reduced considerably in the presence of menthol compared to those for control (without enhancer). The present findings suggest the enantio-selective permeation of SPL across the guinea pig skin in the presence of menthol.

authors

• Khan, Mansoor
• Reddy, Indra

published proceedings

• Drug Dev Ind Pharm

author list (cited authors)

• Zahir, A., Kunta, J. R., Khan, M. A., & Reddy, I. K.

citation count

• 13

complete list of authors

• Zahir, A||Kunta, JR||Khan, MA||Reddy, IK

publication date

• September 1998

publisher

• Taylor & Francis  Publisher

published in

• n0363-9045ISSN  Journal

keywords

• Abdomen
• Adrenergic Beta-Antagonists
• Animals
• Guinea Pigs
• In Vitro Techniques
• Menthol
• Permeability
• Propranolol
• Skin
• Stereoisomerism

PubMed Central ID

• 9876540

Digital Object Identifier (DOI)

• 10.3109/03639049809088534

start page

• 875

end page

• 878

volume

• 24

issue

• 9

URL

• http://dx.doi.org/10.3109/03639049809088534