Artificial neural network and simplex optimization for mixing of aqueous-coated beads to obtain controlled-release formulations Academic Article uri icon


  • The authors explored the use of simplex optimization and artificial neural network (ANN) procedures to obtain coated beads with desired release characteristics by mixing several beads of known strengths and release characteristics. They compared the modeling and optimization abilities of simplex and ANN procedures and in this article present their results and conclusions.

published proceedings

  • Pharmaceutical Technology

author list (cited authors)

  • Vaithiyalingam, S., Zaghloul, A. A., Reddy, I. K., & Khan, M. A.

complete list of authors

  • Vaithiyalingam, S||Zaghloul, AA||Reddy, IK||Khan, MA

publication date

  • June 2000