Complexation of risperidone with a taste-masking resin: novel application of near infra-red and chemical imaging to evaluate complexes. Academic Article

abstract

• The purpose of the study was to investigate the complexation between a weakly basic drug (risperidone) and an ion exchange resin (amberlite IRP-64) used as a taste-masking agent via two preparation methods: physical mixture and solvent evaporation. Both methods were prepared in different drug-to-resin ratios by weight (1:1, 1:2, 1:4, 1:6). Physicochemical characterizations were performed using differential scanning calorimetry, x-ray diffraction, infra-red spectroscopy, Raman spectroscopy, near infra-red spectroscopy, chemical imaging and drug release studies. These physicochemical techniques revealed that risperidone formed complex with the resin via the solvent evaporation method where enhanced dissolution occurred but not with the physical mixtures.

authors

• Khan, Mansoor

published proceedings

• Pharm Dev Technol

author list (cited authors)

• Tawakkul, M. A., Shah, R. B., Zidan, A., Sayeed, V. A., & Khan, M. A.

citation count

• 25

complete list of authors

• Tawakkul, Mobin A||Shah, Rakhi B||Zidan, Ahmed||Sayeed, Vilayat A||Khan, Mansoor A

publication date

• August 2009

publisher

• Taylor & Francis  Publisher

published in

• PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY  Journal

keywords

• Antipsychotic Agents
• Calorimetry, Differential Scanning
• Chemistry, Pharmaceutical
• Resins, Synthetic
• Risperidone
• Solubility
• Solvents
• Spectrum Analysis
• Taste
• X-Ray Diffraction

Digital Object Identifier (DOI)

• 10.1080/10837450802712666

start page

• 409

end page

• 421

volume

• 14

issue

• 4

URL

• http://dx.doi.org/10.1080/10837450802712666