Implications of a carboxylate-bound C-cluster structure of carbon monoxide dehydrogenase. Academic Article uri icon


  • Seeing the C: Nickel-containing carbon monoxide dehydrogenases reversibly oxidize CO to CO2 at a {[Fe3S4]:[Ni Fe a]} active site known as the C-cluster. Recently reported structures of the enzyme by Jeoung and Dobbek, including those of CO2-bound and OH-bound intermediates, shed new light on the enzyme's catalytic mechanism. This Highlight describes these developments and their implications. (Chemical Equation Presented) 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

published proceedings

  • Angew Chem Int Ed Engl

author list (cited authors)

  • Lindahl, P. A.

citation count

  • 26

complete list of authors

  • Lindahl, Paul A

publication date

  • May 2008