Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome. Academic Article

abstract

• Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats, but not in sham controls.

authors

• Burgess, Kevin

published proceedings

• Life Sci

author list (cited authors)

• Malin, D. H., Lake, J. R., Arcangeli, K. R., Deshotel, K. D., Hausam, D. D., Witherspoon, W. E., ... Burgess, K.

citation count

• 25

complete list of authors

• Malin, DH||Lake, JR||Arcangeli, KR||Deshotel, KD||Hausam, DD||Witherspoon, WE||Carter, VA||Yang, HY||Pal, B||Burgess, K

publication date

• January 1993

publisher

• Elsevier  Publisher

published in

• LIFE SCIENCES  Journal

keywords

• Amino Acid Sequence
• Animals
• Injections, Subcutaneous
• Male
• Molecular Sequence Data
• Morphine
• Morphine Dependence
• Neuropeptides
• Oligopeptides
• Rats
• Rats, Sprague-Dawley
• Substance Withdrawal Syndrome

PubMed Central ID

• 8412495

Digital Object Identifier (DOI)

• 10.1016/0024-3205(93)90601-x

start page

• PL261

end page

• PL266

volume

• 53

issue

• 17

URL

• http://dx.doi.org/10.1016/0024-3205(93)90601-x