Resin effects in solid phase SnAr and Sn2 macrocyclizations Academic Article uri icon


  • Seven different supports were compared in solid-phase S(N)Ar and S(N)2 macrocyclization reactions. Product purities were assayed for a relatively facile ring-closure process to give products 1 and 3. Some less-facile ring-closure reactions give the undesired dimeric macrocyclization by-products 2; some of these more-demanding ring closures were also examined. Finally, experiments were performed to gauge the rate of cyclizations on different resins, and some qualitative data were obtained for this.

altmetric score

  • 3

author list (cited authors)

  • Feng, Y., & Burgess, K.

citation count

  • 10

publication date

  • January 2000