Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC
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Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects.
author list (cited authors)
Zhang, A. J., Khare, S., Gokulan, K., Linthicum, D. S., & Burgess, K.