Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC Academic Article uri icon

abstract

  • Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects.

author list (cited authors)

  • Zhang, A. J., Khare, S., Gokulan, K., Linthicum, D. S., & Burgess, K.

citation count

  • 10

publication date

  • January 2001