Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC. Academic Article

abstract

• Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects.

authors

• Burgess, Kevin

published proceedings

• Bioorg Med Chem Lett

author list (cited authors)

• Zhang, A. J., Khare, S., Gokulan, K., Linthicum, D. S., & Burgess, K.

citation count

• 11

complete list of authors

• Zhang, AJ||Khare, S||Gokulan, K||Linthicum, DS||Burgess, K

publication date

• January 2001

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

keywords

• Cell Line
• Combinatorial Chemistry Techniques
• Dimerization
• Humans
• Kinetics
• Ligands
• Molecular Mimicry
• Neurotrophin 3
• Peptides
• Protein Structure, Secondary
• Receptor, Trkc
• Receptors, Nerve Growth Factor
• Structure-Activity Relationship
• Transfection

PubMed Central ID

• 11206460

Digital Object Identifier (DOI)

• 10.1016/s0960-894x(00)00618-1

start page

• 207

end page

• 210

volume

• 11

issue

• 2

URL

• http://dx.doi.org/10.1016/s0960-894x(00)00618-1