Ring closure to beta-turn mimics via copper-catalyzed azide/alkyne cycloadditions. Academic Article uri icon


  • [Structure: see text]. Copper-catalyzed azide alkyne cycloadditions of the linear substrates 1 were used to form the cyclic derivatives 2. Computational, NMR, and CD analyses of these compounds indicate that their most favorable conformational states include type I and type II beta-turn conformations. Selectivity for the dimeric products 6 in these cyclization reactions is discussed.

published proceedings

  • J Org Chem

altmetric score

  • 6

author list (cited authors)

  • Angell, Y. u., & Burgess, K.

citation count

  • 127

complete list of authors

  • Angell, Yu||Burgess, Kevin

publication date

  • November 2005