Base Dependence in Copper‐Catalyzed Huisgen Reactions: Efficient Formation of Bistriazoles
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(Chemical Equation Presented) Click, click: Using a carbonate base as an additive in the copper-accelerated click reaction of alkynes and azides led to an oxidative coupling to form predominately 5,5′-bistriazoles (see scheme). The reaction proved more facile for propargylic ethers and less hindered substrates. Use of an optically active azide gave separable atropisomeric products and provides a convenient access to optically pure derivatives. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
author list (cited authors)
Angell, Y. u., & Burgess, K.