Base Dependence in Copper‐Catalyzed Huisgen Reactions: Efficient Formation of Bistriazoles Academic Article uri icon

abstract

  • (Chemical Equation Presented) Click, click: Using a carbonate base as an additive in the copper-accelerated click reaction of alkynes and azides led to an oxidative coupling to form predominately 5,5′-bistriazoles (see scheme). The reaction proved more facile for propargylic ethers and less hindered substrates. Use of an optically active azide gave separable atropisomeric products and provides a convenient access to optically pure derivatives. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

altmetric score

  • 3

author list (cited authors)

  • Angell, Y. u., & Burgess, K.

citation count

  • 93

publication date

  • May 2007

publisher