Asymmetric hydrogenation approaches to valuable, acyclic 1,3-hydroxymethyl chirons. Academic Article uri icon

abstract

  • An iridium carbene oxazoline complex was used to catalyze hydrogenations of trisubstituted alkenes to give terminal and internal 1,3-hydroxymethyl chirons. The products are accessible in all possible stereoisomeric forms. These hydrogenations do not require strongly coordinating functionalities on the substrate, and in some key cases, catalyst- rather than substrate-controlled stereoselectivities are observed. It is hypothesized that these reactions would not be feasible using iridium or rhodium diphosphine complexes.

author list (cited authors)

  • Zhu, Y. e., & Burgess, K

complete list of authors

  • Zhu, Ye||Burgess, Kevin

publication date

  • January 1, 2008 11:11 AM