Asymmetric hydrogenation approaches to valuable, acyclic 1,3-hydroxymethyl chirons. Academic Article uri icon


  • An iridium carbene oxazoline complex was used to catalyze hydrogenations of trisubstituted alkenes to give terminal and internal 1,3-hydroxymethyl chirons. The products are accessible in all possible stereoisomeric forms. These hydrogenations do not require strongly coordinating functionalities on the substrate, and in some key cases, catalyst- rather than substrate-controlled stereoselectivities are observed. It is hypothesized that these reactions would not be feasible using iridium or rhodium diphosphine complexes.

published proceedings

  • J Am Chem Soc

author list (cited authors)

  • Zhu, Y. e., & Burgess, K.

citation count

  • 45

complete list of authors

  • Zhu, Ye||Burgess, Kevin

publication date

  • July 2008