An asymmetric hydrogenation route to (-)-spongidepsin. Academic Article

abstract

• (-)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to give several spongidepsin analogues, and their cytotoxicities were compared with those of the natural product.

authors

• Burgess, Kevin

published proceedings

• Org Lett

author list (cited authors)

• Zhu, Y. e., Loudet, A., & Burgess, K.

citation count

• 25

complete list of authors

• Zhu, Ye||Loudet, Aurore||Burgess, Kevin

publication date

• October 2010

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Biological Products
• Catalysis
• Cell Proliferation
• Depsipeptides
• Dimerization
• HEK293 Cells
• Humans
• Hydrogenation
• Iridium
• Molecular Structure
• Stereoisomerism

PubMed Central ID

• 20822172

Digital Object Identifier (DOI)

• 10.1021/ol1018773

start page

• 4392

end page

• 4395

volume

• 12

issue

• 19

URL

• http://dx.doi.org/10.1021/ol1018773