An asymmetric hydrogenation route to (-)-spongidepsin. Academic Article uri icon


  • (-)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to give several spongidepsin analogues, and their cytotoxicities were compared with those of the natural product.

published proceedings

  • Org Lett

author list (cited authors)

  • Zhu, Y. e., Loudet, A., & Burgess, K.

citation count

  • 25

complete list of authors

  • Zhu, Ye||Loudet, Aurore||Burgess, Kevin

publication date

  • October 2010