An asymmetric hydrogenation route to (-)-spongidepsin.
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(-)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to give several spongidepsin analogues, and their cytotoxicities were compared with those of the natural product.
author list (cited authors)
Zhu, Y. e., Loudet, A., & Burgess, K.
complete list of authors
Zhu, Ye||Loudet, Aurore||Burgess, Kevin