Pyrrole-based scaffolds for turn mimics. Academic Article

abstract

• Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 -turn and with an inverse -turn.

authors

• Burgess, Kevin

published proceedings

• Org Lett

altmetric score

• 3

author list (cited authors)

• Ko, E., & Burgess, K.

citation count

• 24

complete list of authors

• Ko, Eunhwa||Burgess, Kevin

publication date

• March 2011

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Amines
• Amino Acids
• Combinatorial Chemistry Techniques
• Cyclization
• Models, Molecular
• Molecular Structure
• Peptidomimetics
• Protein Structure, Secondary
• Pyrroles

PubMed Central ID

• 21268601

Digital Object Identifier (DOI)

• 10.1021/ol103022m

start page

• 980

end page

• 983

volume

• 13

issue

• 5

URL

• http://dx.doi.org/10.1021/ol103022m