BODIPY dyes in photodynamic therapy. Academic Article

abstract

• BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with (3)O(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

authors

• Burgess, Kevin

published proceedings

• Chem Soc Rev

altmetric score

• 6

author list (cited authors)

• Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K.

citation count

• 1504

complete list of authors

• Kamkaew, Anyanee||Lim, Siang Hui||Lee, Hong Boon||Kiew, Lik Voon||Chung, Lip Yong||Burgess, Kevin

publication date

• January 2013

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Chemical Society Reviews  Journal

keywords

• Boron Compounds
• Fluorescent Dyes
• Photochemotherapy
• Photosensitizing Agents

PubMed Central ID

• 23014776

Digital Object Identifier (DOI)

• 10.1039/c2cs35216h

start page

• 77

end page

• 88

volume

• 42

issue

• 1

URL

• http://dx.doi.org/10.1039/c2cs35216h