Flow oscillation is a crucial issue for the development of flow boiling heat transfer in the applications. Inlet orifice has been proven be an option to eliminate the oscillation. However, the effects of inlet orifice on critical heat flux and flow boiling heat transfer coefficient are lack of study. In this work, the effects of inlet restriction on critical heat flux and heat transfer coefficient in single horizontal microtube under uniform heating condition is experimentally investigated using FC-72 as working fluid. A stainless steel microtube with an inner diameter of 889 m is selected as main microtube. Two smaller microtubes are assembled at the inlet of main microtube to achieve the restriction configurations of 50% and 20% area ratios. The experimental measurement is carried out at mass fluxes ranging from 160870 kg/m2s and heat fluxes varying from 6170 kW/m2. Two saturation pressures, 10 and 45 kPa, are tested. The experimental results of critical heat flux and two phase heat transfer coefficient obtained in the microtube without orifice are compared with the existing correlations. The addition of an orifice does not enhance the normal critical heat flux but increases the premature critical heat flux. In aspect of heat transfer, the orifice shows improvement on heat transfer coefficient at low mass flux and high saturation pressure.