MEASUREMENT OF INFINITE DILUTION ACTIVITY-COEFFICIENTS USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
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Economou, I.G., Vimalchand, P. and Donohue, M.D., 1991. Measurement of infinite dilution activity coefficients using high performance liquid chromatography. Fluid Phase Equilibria, 68: 131-149. High performance liquid chromatography (HPLC) was used to measure the distribution of several solutes between a stationary phase and a mobile phase. In all cases, the stationary phase was octadecane bonded to PORASIL packing material. Mobile phases were aqueous solutions of methanol, ethanol, acetonitrile and isopropanol at several compositions. Solutes were benzene, toluene, p-xylene and cumene. These solutes show good partitioning between the two phases and are easily detected with a UV detector. Ratios of infinite dilution activity coefficients, , of these solutes in the mobile phases were then determined from the capacity factor k'. Values for the activity coefficients themselves can be obtained from these ratios if one absolute value is available. Our results compare well with values of for the same systems obtained from the literature. Limitations of the method are discussed. Finally, experimental results are compared with predictions from UNIFAC, NRTL and APACT. 1991.