Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes Academic Article uri icon

abstract

  • Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains approximately 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

altmetric score

  • 6

author list (cited authors)

  • Feng, J. Q., Harris, M. A., Ghosh-Choudhury, N., Feng, M., Mundy, G. R., & Harris, S. E.

citation count

  • 65

publication date

  • June 1994