Expression of the BMP 2 gene during bone cell differentiation. Academic Article

abstract

• Bone morphogenetic protein 2 (BMP 2) and transforming growth factor beta (TGF beta) are actively involved in bone formation and remodeling. TGF beta, a powerful stimulant in the early stage of bone cell growth and matrix formation, inhibits differentiation and in vitro mineralized nodule formation in primary fetal rat calvarial osteoblast system. TGF beta also negatively regulates BMP 2 expression at the transcriptional level. BMP 2 gene expression is controlled by a battery of transcriptional factors, some known and some yet to be identified. Immortalized osteoblast cell lines generated from a transgenic mouse carrying BMP 2 promoter-driven SV40 large T antigen transgene are described as powerful tools for studying regulation of BMP 2 gene expression and bone cell differentiation at the molecular level.

authors

• Feng, Jian

published proceedings

• Crit Rev Eukaryot Gene Expr

altmetric score

• 9

author list (cited authors)

• Ghosh-Choudhury, N., Harris, M. A., Feng, J. Q., Mundy, G. R., & Harris, S. E.

citation count

• 68

complete list of authors

• Ghosh-Choudhury, N||Harris, MA||Feng, JQ||Mundy, GR||Harris, SE

publication date

• January 1994

publisher

• Begell House  Publisher

published in

• Critical Reviews in Eukaryotic Gene Expression  Journal

keywords

• Animals
• Bone And Bones
• Bone Morphogenetic Proteins
• Cell Differentiation
• Gene Expression Regulation, Developmental
• Helix-loop-helix Motifs
• Mice
• Mice, Transgenic
• Osteoblasts
• Proteins
• Rats
• Regulatory Sequences, Nucleic Acid
• Transcription Factors
• Transforming Growth Factor Beta

PubMed Central ID

• 7881166

Digital Object Identifier (DOI)

• 10.1615/critreveukargeneexpr.v4.i2-3.30

start page

• 345

end page

• 355

volume

• 4

issue

• 2-3

URL

• http://dx.doi.org/10.1615/critreveukargeneexpr.v4.i2-3.30