Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. Academic Article uri icon


  • A novel MRI method--diffusion tensor imaging--was used to compare the integrity of several white matter fibre tracts in patients with probable Alzheimer's disease. Relative to normal controls, patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longitudinal fasciculus, and cingulum. By contrast, pyramidal tract integrity seemed unchanged. This novel finding is consistent with the clinical presentation of probable Alzheimer's disease, in which global cognitive decline is a more prominent feature than motor disturbance.

published proceedings

  • J Neurol Neurosurg Psychiatry

altmetric score

  • 6

author list (cited authors)

  • Rose, S. E., Chen, F., Chalk, J. B., Zelaya, F. O., Strugnell, W. E., Benson, M., Semple, J., & Doddrell, D. M.

citation count

  • 400

complete list of authors

  • Rose, SE||Chen, F||Chalk, JB||Zelaya, FO||Strugnell, WE||Benson, M||Semple, J||Doddrell, DM

publication date

  • October 2000


  • BMJ  Publisher