Part 2. Notch-sparing -secretase inhibitors: The study of novel -amino naphthyl alcohols.
Additional Document Info
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by -secretase. At the beginning of a series of studies from our laboratories, a series of novel -amino alcohols (1) were found to possess -secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of -amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.