Part 2. Notch-sparing -secretase inhibitors: The study of novel -amino naphthyl alcohols. Academic Article uri icon


  • One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by -secretase. At the beginning of a series of studies from our laboratories, a series of novel -amino alcohols (1) were found to possess -secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of -amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.

published proceedings

  • Bioorg Med Chem Lett

altmetric score

  • 7

author list (cited authors)

  • Wei, H., Lu, D., Sun, V., Zhang, J., Gu, Y., Osenkowski, P., ... Augelli-Szafran, C. E.

citation count

  • 4

complete list of authors

  • Wei, Han-Xun||Lu, Dai||Sun, Vivien||Zhang, Jing||Gu, Yongli||Osenkowski, Pamela||Ye, Wenjuan||Selkoe, Dennis J||Wolfe, Michael S||Augelli-Szafran, Corinne E

publication date

  • January 2016