Part 2. Notch-sparing -secretase inhibitors: The study of novel -amino naphthyl alcohols. Academic Article

abstract

• One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by -secretase. At the beginning of a series of studies from our laboratories, a series of novel -amino alcohols (1) were found to possess -secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of -amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.

authors

• Lu, Dai

published proceedings

• Bioorg Med Chem Lett

altmetric score

• 7

author list (cited authors)

• Wei, H., Lu, D., Sun, V., Zhang, J., Gu, Y., Osenkowski, P., ... Augelli-Szafran, C. E.

citation count

• 4

complete list of authors

• Wei, Han-Xun||Lu, Dai||Sun, Vivien||Zhang, Jing||Gu, Yongli||Osenkowski, Pamela||Ye, Wenjuan||Selkoe, Dennis J||Wolfe, Michael S||Augelli-Szafran, Corinne E

publication date

• May 2016

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

keywords

• Alzheimer’s Disease
• Amino Alcohols
• Amyloid Beta-Peptides
• Amyloid Precursor Protein Secretases
• Animals
• Aβ Production
• Humans
• Microsomes, Liver
• Naphthalenes
• Notch-processing
• Peptide Fragments
• Propanolamines
• Protease Inhibitors
• Rats
• Receptor, Notch1
• Structure-Activity Relationship
• γ-amino Alcohols
• γ-secretase Inhibitors

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2016.03.042

start page

• 2133

end page

• 2137

volume

• 26

issue

• 9

URL

• http://dx.doi.org/10.1016/j.bmcl.2016.03.042