Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols Academic Article uri icon

abstract

  • One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of γ-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.

altmetric score

  • 7

author list (cited authors)

  • Wei, H., Lu, D., Sun, V., Zhang, J., Gu, Y., Osenkowski, P., ... Augelli-Szafran, C. E.

citation count

  • 2

publication date

  • May 2016