Raised cerebrospinal-fluid copper concentration in Parkinson's disease. Academic Article

abstract

• The cerebrospinal-fluid copper concentration, measured by electrothermal atomisation/atomic absorption spectrophotometry, was significantly higher in 24 patients with untreated, idiopathic Parkinson's disease than in a control population of 34 patients (p less than 0.001). The difference in the in-vitro capacity of copper to damage DNA, measured by the phenanthroline assay was even greater. The high phenanthroline-copper concentration correlated with disease severity (p = 0.02) and with the rate of progression of disease (p less than 0.05). A possible role is suggested for copper-catalysed oxidative mechanisms in the pathogenesis of Parkinson's disease.

authors

• Hall, Michael

published proceedings

• Lancet

altmetric score

• 7

author list (cited authors)

• Pall, H. S., Williams, A. C., Blake, D. R., Lunec, J., Gutteridge, J. M., Hall, M., & Taylor, A.

citation count

• 181

complete list of authors

• Pall, HS||Williams, AC||Blake, DR||Lunec, J||Gutteridge, JM||Hall, M||Taylor, A

publication date

• August 1987

publisher

• Elsevier  Publisher

published in

• The Lancet  Journal

keywords

• Adult
• Copper
• Female
• Humans
• Iron
• Male
• Manganese
• Middle Aged
• Parkinson Disease
• Phenanthrolines
• Severity Of Illness Index
• Spectrophotometry, Atomic

PubMed Central ID

• 2886715

Digital Object Identifier (DOI)

• 10.1016/s0140-6736(87)90827-0

start page

• 238

end page

• 241

volume

• 2

issue

• 8553

URL

• http://dx.doi.org/10.1016/s0140-6736(87)90827-0