Raised cerebrospinal-fluid copper concentration in Parkinson's disease. Academic Article uri icon


  • The cerebrospinal-fluid copper concentration, measured by electrothermal atomisation/atomic absorption spectrophotometry, was significantly higher in 24 patients with untreated, idiopathic Parkinson's disease than in a control population of 34 patients (p less than 0.001). The difference in the in-vitro capacity of copper to damage DNA, measured by the phenanthroline assay was even greater. The high phenanthroline-copper concentration correlated with disease severity (p = 0.02) and with the rate of progression of disease (p less than 0.05). A possible role is suggested for copper-catalysed oxidative mechanisms in the pathogenesis of Parkinson's disease.

published proceedings

  • Lancet

altmetric score

  • 7

author list (cited authors)

  • Pall, H. S., Williams, A. C., Blake, D. R., Lunec, J., Gutteridge, J. M., Hall, M., & Taylor, A.

citation count

  • 181

complete list of authors

  • Pall, HS||Williams, AC||Blake, DR||Lunec, J||Gutteridge, JM||Hall, M||Taylor, A

publication date

  • August 1987