Distance measure-based algorithm for identification of protein complexes
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abstract
IPC-DM, is proposed based on our discovery that most of the shortest paths between proteins complexes are no more than two. A new seed-extension model is also proposed to improve the precision of protein complexes discovery. Experiment results on yeast protein interaction network show that more known protein complexes are recalled by IPC-DM than by other typical algorithms: MCODE, ENSC, CFinder, LCMA and DPClus.