Arachidonic acid, prostaglandin E2 and F2 alpha inhibit leucine degradation in chick skeletal muscle. Academic Article

abstract

• Arachidonic acid (5 microM), prostaglandin E2 (0.28 microM) and F2 alpha (14 microM) inhibited (P less than 0.01) the rates of net leucine transamination, leucine oxidative decarboxylation and total CO2 production from leucine in extensor digitorum communis muscles from fed ten-day-old chicks. Indomethacin (50 microM) markedly inhibited (P less than 0.01) the rate of PGE2 production in the presence of 5 microM arachidonic acid and prevented the inhibition of leucine degradation by arachidonic acid in skeletal muscle. These results demonstrate that the actions of arachidonic acid on leucine degradation in chick skeletal muscle are mediated by metabolites generated via the cyclooxygenase pathway and that prostaglandins may play a role in the regulation of leucine degradation in skeletal muscle.

authors

• Wu, Guoyao

published proceedings

• Biochem Int

author list (cited authors)

• Wu, G., & Thompson, J. R.

citation count

• 1

complete list of authors

• Wu, G||Thompson, JR

publication date

• February 1988

published in

• Biochemistry International  Journal

keywords

• Animals
• Arachidonic Acid
• Arachidonic Acids
• Chickens
• Dinoprost
• Dinoprostone
• Indomethacin
• Leucine
• Muscles
• Prostaglandins E
• Prostaglandins E, Synthetic
• Prostaglandins F

PubMed Central ID

• 3130060

start page

• 227

end page

• 234

volume

• 16

issue

• 2