Ketone bodies inhibit leucine degradation in chick skeletal muscle.

abstract

• 1. DL-beta-hydroxybutyrate (4 mM) increased the net rate of leucine transamination and the net rate of 2-oxoisocaproate (KIC) production in extensor digitorum communis muscles from fed chicks. 2. DL-beta-hydroxybutyrate at 1 and 4 mM inhibited leucine oxidative decarboxylation in muscles from fed chicks. 3. Acetoacetate at 1 and 4 mM inhibited leucine oxidative decarboxylation and total leucine oxidation, but increased net KIC production in muscles from fed chicks. 4. Both DL-beta-hydroxybutyrate and acetoacetate at 1 and 4 mM inhibited the net rate of leucine transamination and the rates of leucine oxidative decarboxylation and total leucine oxidation in muscles from 24-hr fasted chicks.

authors

• Wu, Guoyao

published proceedings

• Int J Biochem

altmetric score

• 6

author list (cited authors)

• Wu, G., & Thompson, J. R.

citation count

• 28

complete list of authors

• Wu, G||Thompson, JR

publication date

• January 1987

publisher

• Elsevier  Publisher

published in

• n0020-711XISSN  Journal

keywords

• Acetoacetates
• Animals
• Chick Embryo
• Fasting
• Ketone Bodies
• Leucine
• Muscles

PubMed Central ID

• 3666283

Digital Object Identifier (DOI)

• 10.1016/0020-711x(87)90175-3

start page

• 937

end page

• 943

volume

• 19

issue

• 10

URL

• http://dx.doi.org/10.1016/0020-711x(87)90175-3