Ketone bodies inhibit leucine degradation in chick skeletal muscle. Academic Article uri icon

abstract

  • 1. DL-beta-hydroxybutyrate (4 mM) increased the net rate of leucine transamination and the net rate of 2-oxoisocaproate (KIC) production in extensor digitorum communis muscles from fed chicks. 2. DL-beta-hydroxybutyrate at 1 and 4 mM inhibited leucine oxidative decarboxylation in muscles from fed chicks. 3. Acetoacetate at 1 and 4 mM inhibited leucine oxidative decarboxylation and total leucine oxidation, but increased net KIC production in muscles from fed chicks. 4. Both DL-beta-hydroxybutyrate and acetoacetate at 1 and 4 mM inhibited the net rate of leucine transamination and the rates of leucine oxidative decarboxylation and total leucine oxidation in muscles from 24-hr fasted chicks.

published proceedings

  • Int J Biochem

altmetric score

  • 6

author list (cited authors)

  • Wu, G., & Thompson, J. R.

citation count

  • 28

complete list of authors

  • Wu, G||Thompson, JR

publication date

  • January 1987