Gene expression, signal transduction and tissue-specific biomineralization during mammalian tooth development. Academic Article uri icon


  • Tooth development provides a paradigm for intrinsic molecular controls for cell- and extracellular matrix (ECM)-mediated biomineralization. The intent of this review is to evaluate the sequential timing and positional information prerequisite for tissue-specific biomineralization. Recent investigations suggest that 1,25-dihydroxyvitamin D3 functions to up-regulate VDR (vitamin D receptor) that in turn could induce structural gene products, including calcium-binding proteins and several ECM proteins (e.g., enamelins, amelogenins, dentine sialoglycoproteins (DSP) and dentine phosphoproteins (DPP)), resulting in dentine and enamel formation. Inhibition of regulatory gene products and/or their receptors likely results in hypoplastic and/or hypomineralized ECM as a direct consequence of down-regulated (1) transcription and/or translation of structural and regulatory genes, (2) posttranslational modifications, (3) and/or decreased calcium transport to the forming dentine and enamel matrices. Advances in serumless in vitro culture methodology; computer-assisted access to nucleic acid sequences for probes to define when, where, and how many specific regulatory and structural gene products are expressed; antisense oligodeoxynucleotides to inhibit specific translation; and microtechniques to analyze biomineralization all provide additional avenues to investigate tissue-specific biomineralization.

published proceedings

  • Crit Rev Eukaryot Gene Expr

author list (cited authors)

  • Slavkin, H. C., Hu, C. C., Sakakura, Y., Diekwisch, T., Chai, Y., Mayo, M., ... Sasano, Y.

citation count

  • 18

complete list of authors

  • Slavkin, HC||Hu, CC||Sakakura, Y||Diekwisch, T||Chai, Y||Mayo, M||Bringas, P||Simmer, J||Mak, G||Sasano, Y

publication date

  • December 1992