Chondrocyte-matrix attachment complexes mediate survival and differentiation. Academic Article

abstract

• Integrin mediated cell-extracellular matrix interactions are required for survival and differentiation of many cell types. In this review, the cell-matrix attachment complex (CMAX) is described for chondrocytes. The evidence that integrin-mediated signal transduction is necessary for normal chondrocyte differentiation and survival in various culture conditions and in vivo are reviewed. The possible signal transduction pathways stimulated by the extracellular matrix components are discussed with a review of current data from chondrocyte experiments. In addition, the influence of parathyroid hormone and transforming growth factor beta on chondrocyte survival has been included as they may function in concert with integrin mediated signal transduction. Finally, specific changes in gene expression preceding apoptosis are discussed. The current understanding of how integrin-mediated signals prevent apoptosis and implications of anchorage-dependent survival for development and differentiation of the chondrocyte phenotype are discussed.

authors

• Svoboda, Kathy

published proceedings

• Microsc Res Tech

altmetric score

• 3

author list (cited authors)

• Svoboda, K. K.

citation count

• 42

complete list of authors

• Svoboda, KK

publication date

• October 1998

published in

• Microscopy Research and Technique  Journal

keywords

• Animals
• Cell Differentiation
• Cell Survival
• Chondrocytes
• Extracellular Matrix
• Humans
• Macromolecular Substances
• Signal Transduction

PubMed Central ID

• 9822998

Digital Object Identifier (DOI)

• 10.1002/(SICI)1097-0029(19981015)43:2<111::AID-JEMT4>3.0.CO;2-O

start page

• 111

end page

• 122

volume

• 43

issue

• 2