Citrus limonoids: Increasing importance as anticancer agents Academic Article uri icon


  • Limonoids have repeatedly been shown to possess anticancer activity in animals. As an outgrowth of this research, scientists are now working on the development of new foods containing elevated concentrations of limonoids. To recapture the additional funds needed to produce these products claims will have to be made on potential health benefits. This paper will review our research on the antineoplastic activity of 12 citrus limonoids. The data from these experiments have shown that some of the structural features associated with the limonoid nucleus are critical to cancer chemopreventive activity. The data from our recent studies on the effect of limonoid glucosides in mammalian systems will also be presented. Research with animals and human cells grown in culture suggest that these citrus chemicals are safe at elevated concentrations.

published proceedings

  • ACS Symposium Series

author list (cited authors)

  • Miller, E. G., Taylor, S. E., Berry, C. W., Zimmerman, J. A., & Hasegawa, S

complete list of authors

  • Miller, EG||Taylor, SE||Berry, CW||Zimmerman, JA||Hasegawa, S

publication date

  • December 2000